This article is from Molecular Vision, volume 20.AbstractPurpose: Εnhanced expression of transcription factor hypoxia inducible factor HIF-1α is known to play a critical role in the modulation of cell metabolism and survival pathways as well as having stem-cell–like properties. Furthermore, accumulated data reveal the existence of cross-regulation between the oxygen-sensing and heat shock pathways contributing to the adaptation of cells under stressful conditions. Pterygium, a stem cell... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976686
byAcharya, Moulinath; Sharp, Michael W.; Mirzayans, Farideh; Footz, Tim; Huang, LiJia; Birdi, Chanchal; Walter, Michael A.
This article is from Molecular Vision, volume 18.AbstractPurpose: Mutations in the homeobox transcription factor paired-like homeodomain transcription factor 2 (PITX2) cause Axenfeld–Reiger syndrome (ARS), which is associated with anterior segment dysgenesis (ASD) and glaucoma. To understand ARS pathogenesis, it is essential to know the normal functions of PITX2 and the proteins with which PITX2 interacts in the eye. Therefore, we used a unique cDNA library that we created from human... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425575